Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness | Zendy

Demelza Koehn | Zendy; Kacie J. Meyer | Zendy; Michael G. Anderson | Zendy

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Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness

Author(s) -

Demelza Koehn,

Kacie J. Meyer,

Michael G. Anderson

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17179

Subject(s) - quantitative trait locus , biology , keratoconus , genetics , inbred strain , single nucleotide polymorphism , locus (genetics) , genome wide association study , stromal cell , cornea , genetic architecture , candidate gene , genotype , gene , cancer research , neuroscience

Central corneal thickness (CCT) is a quantitative trait associated with keratoconus and primary open-angle glaucoma. Although CCT is highly heritable, known genetic variations explain only a fraction of the phenotypic variability. The purpose of this study was to identify additional CCT-influencing loci using inbred strains of mice.

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