A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a “Humanized” HLA Transgenic Rabbit Model | Zendy

Ruchi Srivastava | Zendy; Arif A. Khan | Zendy; Jiawei Huang | Zendy; Anthony B. Nesburn | Zendy; Steven L. Wechsler | Zendy; Lbachir BenMohamed | Zendy

Open Access

A Herpes Simplex Virus Type 1 Human Asymptomatic CD8⁺T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a “Humanized” HLA Transgenic Rabbit Model

Author(s) -

Ruchi Srivastava,

Arif A. Khan,

Jiawei Huang,

Anthony B. Nesburn,

Steven L. Wechsler,

Lbachir BenMohamed

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17074

Subject(s) - herpes simplex virus , epitope , cd8 , virology , cytotoxic t cell , immunology , t cell , biology , virus , adjuvant , medicine , antigen , immune system , in vitro , biochemistry

A clinical vaccine that protects from ocular herpes simplex virus type 1 (HSV-1) infection and disease still is lacking. In the present study, preclinical vaccine trials of nine asymptomatic (ASYMP) peptides, selected from HSV-1 glycoproteins B (gB), and tegument proteins VP11/12 and VP13/14, were performed in the "humanized" HLA-transgenic rabbit (HLA-Tg rabbit) model of ocular herpes. We recently reported that these peptides are highly recognized by CD8+ T cells from "naturally" protected HSV-1-seropositive healthy ASYMP individuals (who have never had clinical herpes disease).

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