Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration | Zendy

Allison E. Songstad | Zendy; Luke A. Wiley | Zendy; Khahn Duong | Zendy; Emily Kaalberg | Zendy; Miles J. FlammeWiese | Zendy; Cathryn M. Cranston | Zendy; Megan Riker | Zendy; Da. Levasseur | Zendy; Edwin M. Stone | Zendy; Robert F. Mullins | Zendy; Budd A. Tucker | Zendy

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Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration

Author(s) -

Allison E. Songstad,

Luke A. Wiley,

Khahn Duong,

Emily Kaalberg,

Miles J. FlammeWiese,

Cathryn M. Cranston,

Megan Riker,

Da. Levasseur,

Edwin M. Stone,

Robert F. Mullins,

Budd A. Tucker

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17073

Subject(s) - induced pluripotent stem cell , sox2 , stem cell , biology , endothelial stem cell , klf4 , microbiology and biotechnology , pedf , cd34 , embryonic stem cell , cancer research , angiogenesis , genetics , gene , in vitro

Age-related macular degeneration (AMD), the most common cause of incurable blindness in the western world, is characterized by the dysfunction and eventual death of choroidal endothelial (CECs), RPE, and photoreceptor cells. Stem cell-based treatment strategies designed to replace photoreceptor and RPE cells currently are a major scientific focus. However, the success of these approaches likely also will require replacement of the underlying, supportive choroidal vasculature. The purpose of this study was to generate stem cell-derived CECs to develop efficient differentiation and transplantation protocols.

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