Genetic Variants and Systemic Complement Activation Levels Are Associated With Serum Lipoprotein Levels in Age-Related Macular Degeneration | Zendy

Constantin C. Paun | Zendy; Lebriz Ersoy | Zendy; Tina Schick | Zendy; J.M.M. Groenewoud | Zendy; Yara T. E. Lechanteur | Zendy; Sascha Fauser | Zendy; Carel B. Hoyng | Zendy; Eiko K. de Jong | Zendy; Anneke I. den Hollander | Zendy

Open Access

Genetic Variants and Systemic Complement Activation Levels Are Associated With Serum Lipoprotein Levels in Age-Related Macular Degeneration

Author(s) -

Constantin C. Paun,

Lebriz Ersoy,

Tina Schick,

J.M.M. Groenewoud,

Yara T. E. Lechanteur,

Sascha Fauser,

Carel B. Hoyng,

Eiko K. de Jong,

Anneke I. den Hollander

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17035

Subject(s) - single nucleotide polymorphism , apolipoprotein b , medicine , complement system , lipoprotein , endocrinology , biology , apolipoprotein e , cholesterol , genotype , complement component 3 , genetics , gene , alternative complement pathway , disease , antibody

Genetic variants in genes encoding components of lipid metabolism have been associated with AMD. The aims of this study were to evaluate the relation of these genetic variants with serum lipid levels in AMD in a large case-control cohort (n = 3070) and to test for correlations between lipids and complement activation.

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