CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet | Zendy

Devang L. Bhoiwala | Zendy; Ying Song | Zendy; Alyssa Cwanger | Zendy; Esther Clark | Zendy; Liangliang Zhao | Zendy; Chenguang Wang | Zendy; Yafeng Li | Zendy; Delu Song | Zendy; Joshua L. Dunaief | Zendy

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CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet

Author(s) -

Devang L. Bhoiwala,

Ying Song,

Alyssa Cwanger,

Esther Clark,

Liangliang Zhao,

Chenguang Wang,

Yafeng Li,

Delu Song,

Joshua L. Dunaief

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17026

Subject(s) - ceruloplasmin , ferritin , retina , retinal degeneration , retinal , medicine , oxidative stress , biology , transferrin , endocrinology , macular degeneration , serum iron , transferrin receptor , hemoglobin , biochemistry , ophthalmology , neuroscience

High RPE iron levels have been associated with age-related macular degeneration. Mutation of the ferroxidase ceruloplasmin leads to RPE iron accumulation and degeneration in patients with aceruloplasminemia; mice lacking ceruloplasmin and its homolog hephaestin have a similar RPE degeneration. To determine whether a high iron diet (HID) could cause RPE iron accumulation, possibly contributing to RPE oxidative stress in AMD, we tested the effect of dietary iron on mouse RPE iron.

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