Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in aCNGB3−/−Mouse Model of Achromatopsia | Zendy

Dario Marangoni | Zendy; Camasamudram Vijayasarathy | Zendy; Ronald A. Bush | Zendy; Lisa L. Wei | Zendy; Rong Wen | Zendy; Paul A. Sieving | Zendy

Open Access

Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in aCNGB3^−/−Mouse Model of Achromatopsia

Author(s) -

Dario Marangoni,

Camasamudram Vijayasarathy,

Ronald A. Bush,

Lisa L. Wei,

Rong Wen,

Paul A. Sieving

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-16866

Subject(s) - scotopic vision , ciliary neurotrophic factor , photopic vision , achromatopsia , erg , electroretinography , retinal , endocrinology , biology , chemistry , neurotrophic factors , ophthalmology , medicine , receptor

Ciliary neurotrophic factor (CNTF) was recently shown to augment cone function in CNGB3 mutant achromat dogs. However, testing CNTF-releasing implant in human CNGB3 achromats failed to show benefit. We evaluated the effects of CNTF protein on the retinal function in an additional achromatopsia model, the CNGB3-/- mouse.

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