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Ciliary neurotrophic factor (CNTF) was recently shown to augment cone function in CNGB3 mutant achromat dogs. However, testing CNTF-releasing implant in human CNGB3 achromats failed to show benefit. We evaluated the effects of CNTF protein on the retinal function in an additional achromatopsia model, the CNGB3-/- mouse.

Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in aCNGB3−/−Mouse Model of Achromatopsia

Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in aCNGB3^−/−Mouse Model of Achromatopsia