Alpha2-Adrenergic–Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells | Zendy

Mohammad HarunOrRashid | Zendy; Marta DiazdelCastillo | Zendy; Caridad GalindoRomero | Zendy; Finn Hallböök | Zendy

Open Access

Alpha2-Adrenergic–Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells

Author(s) -

Mohammad HarunOrRashid,

Marta DiazdelCastillo,

Caridad GalindoRomero,

Finn Hallböök

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-16816

Subject(s) - mapk/erk pathway , microbiology and biotechnology , agonist , signal transduction , receptor , downregulation and upregulation , biology , endocrinology , chemistry , medicine , biochemistry , gene

Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-induced ERK and Müller cell dedifferentiation. We tested the hypothesis that α2-stimulation triggers negative feedback regulation of the injury-induced ERK pathway that attenuates Müller cell dedifferentiation.

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