Erp29 Attenuates Cigarette Smoke Extract–Induced Endoplasmic Reticulum Stress and Mitigates Tight Junction Damage in Retinal Pigment Epithelial Cells | Zendy

Chuangxin Huang | Zendy; Joshua J. Wang | Zendy; Guangjun Jing | Zendy; Junhua Li | Zendy; Chenjin Jin | Zendy; Qiang Yu | Zendy; Marek Falkowski | Zendy; Sarah X. Zhang | Zendy

Open Access

Erp29 Attenuates Cigarette Smoke Extract–Induced Endoplasmic Reticulum Stress and Mitigates Tight Junction Damage in Retinal Pigment Epithelial Cells

Author(s) -

Chuangxin Huang,

Joshua J. Wang,

Guangjun Jing,

Junhua Li,

Chenjin Jin,

Qiang Yu,

Marek Falkowski,

Sarah X. Zhang

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-16795

Subject(s) - endoplasmic reticulum , unfolded protein response , microbiology and biotechnology , chop , apoptosis , tight junction , gene knockdown , chemistry , biology , biochemistry

Endoplasmic reticulum protein 29 (ERp29) is a novel chaperone that was recently found decreased in human retinas with AMD. Herein, we examined the effect of ERp29 on cigarette smoke-induced RPE apoptosis and tight junction disruption.

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