Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model | Zendy

Adam M. Hanif | Zendy; Eric C. Lawson | Zendy; Megan Prunty | Zendy; Marissa A. Gogniat | Zendy; Moe H. Aung | Zendy; Ranjay Chakraborty | Zendy; Jeffrey H. Boatright | Zendy; Machelle T. Pardue | Zendy

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Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model

Author(s) -

Adam M. Hanif,

Eric C. Lawson,

Megan Prunty,

Marissa A. Gogniat,

Moe H. Aung,

Ranjay Chakraborty,

Jeffrey H. Boatright,

Machelle T. Pardue

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-16792

Subject(s) - retinal degeneration , retinitis pigmentosa , retinal , neuroprotection , retina , gene therapy of the human retina , macular degeneration , ophthalmology , outer nuclear layer , electroretinography , visual acuity , photoreceptor cell , medicine , biology , anatomy , neuroscience

Our previous investigations showed that involuntary treadmill exercise is neuroprotective in a light-induced retinal degeneration mouse model, and it may act through activation of tropomyosin-related kinase B (TrkB) receptors. This study investigated whether voluntary running wheel exercise can be neuroprotective in an inheritable model of the retinal degenerative disease retinitis pigmentosa (RP), rd10 mice.

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