Open AccessA Novel Approach of Daunorubicin Application on Formation of Proliferative Retinopathy Using a Porous Silicon Controlled Delivery System: Pharmacodynamics
Author(s) -
Huiyuan Hou,
Kristyn Huffman,
Sandy Rios,
William R. Freeman,
Michael J. Sailor,
Lingyun Cheng
Publication year - 2015
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.15-16526
Subject(s) - daunorubicin , proliferative vitreoretinopathy , medicine , pharmacokinetics , retinal detachment , pharmacodynamics , ophthalmology , adverse effect , pharmacology , retinal , surgery , chemotherapy
Proliferative vitreoretinopathy (PVR) is the most common cause of poor visual outcomes in association with retinal detachment surgeries and ocular trauma. Daunorubicin (DNR) has shown the strongest efficacy in proliferation inhibition in vitro. However, clinical studies have shown only mild effect owing to limitations of narrow therapeutic window and short vitreous half-life.