Open AccessSpatiotemporally Regulated Ablation ofKlf4in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis
Author(s) -
Emili E. Delp,
Shivalingappa K. Swamynathan,
Winston W.Y. Kao,
Shivalingappa K. Swamynathan
Publication year - 2015
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.15-16463
Subject(s) - klf4 , microbiology and biotechnology , homeostasis , epithelium , cell , ablation , biology , induced pluripotent stem cell , genetics , medicine , embryonic stem cell , gene
In previous studies, conditional disruption of Klf4 in the developing mouse ocular surface from embryonic day 10 resulted in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells, revealing the importance of Klf4 in ocular surface maturation. Here, we use spatiotemporally regulated ablation of Klf4 to investigate its functions in maintenance of adult corneal epithelial homeostasis.