Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration | Zendy

Susan Murray | Zendy; Ali Jazayeri | Zendy; Michael T. Matthes | Zendy; Douglas Yasumura | Zendy; Haidong Yang | Zendy; Raechel Peralta | Zendy; Andy Watt | Zendy; Sue Freier | Zendy; Gene Hung | Zendy; Peter Adamson | Zendy; Shuling Guo | Zendy; Brett P. Monia | Zendy; Matthew M. LaVail | Zendy; Michael L. McCaleb | Zendy

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Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration

Author(s) -

Susan Murray,

Ali Jazayeri,

Michael T. Matthes,

Douglas Yasumura,

Haidong Yang,

Raechel Peralta,

Andy Watt,

Sue Freier,

Gene Hung,

Peter Adamson,

Shuling Guo,

Brett P. Monia,

Matthew M. LaVail,

Michael L. McCaleb

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-16400

Subject(s) - rhodopsin , retinitis pigmentosa , electroretinography , microbiology and biotechnology , outer nuclear layer , retinal degeneration , transgene , photoreceptor cell , biology , erg , chemistry , retinal , gene , biochemistry

To preserve photoreceptor cell structure and function in a rodent model of retinitis pigmentosa with P23H rhodopsin by selective inhibition of the mutant rhodopsin allele using a second generation antisense oligonucleotide (ASO).

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