Lipofuscin Redistribution and Loss Accompanied by Cytoskeletal Stress in Retinal Pigment Epithelium of Eyes With Age-Related Macular Degeneration | Zendy

Thomas Ach | Zendy; Elen Tolstik | Zendy; Jeffrey D. Messinger | Zendy; Anna V. Zarubina | Zendy; Rainer Heintzmann | Zendy; Christine A. Curcio | Zendy

Open Access

Lipofuscin Redistribution and Loss Accompanied by Cytoskeletal Stress in Retinal Pigment Epithelium of Eyes With Age-Related Macular Degeneration

Author(s) -

Thomas Ach,

Elen Tolstik,

Jeffrey D. Messinger,

Anna V. Zarubina,

Rainer Heintzmann,

Christine A. Curcio

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-16274

Subject(s) - lipofuscin , retinal pigment epithelium , macular degeneration , retina , retinal , fundus (uterus) , pathology , microbiology and biotechnology , biology , anatomy , ophthalmology , medicine , neuroscience

Lipofuscin (LF) and melanolipofuscin (MLF) of the retinal pigment epithelium (RPE) are the principal sources of autofluorescence (AF) signals in clinical fundus-AF imaging. Few details about the subcellular distribution of AF organelles in AMD are available. We describe the impact of aging and AMD on RPE morphology revealed by the distribution of AF LF/MLF granules and actin cytoskeleton in human tissues.

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