Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy | Zendy

Shikun He | Zendy; Ernesto Barrón | Zendy; Keijiro Ishikawa | Zendy; Hossein Nazari Khanamiri | Zendy; Chris Spee | Zendy; Peng Zhou | Zendy; Satoru Kase | Zendy; Zhuoshi Wang | Zendy; Laurie Dustin | Zendy; David R. Hinton | Zendy

Open Access

Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy

Author(s) -

Shikun He,

Ernesto Barrón,

Keijiro Ishikawa,

Hossein Nazari Khanamiri,

Chris Spee,

Peng Zhou,

Satoru Kase,

Zhuoshi Wang,

Laurie Dustin,

David R. Hinton

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-16258

Subject(s) - microbiology and biotechnology , transdifferentiation , dna methylation , methylation , vimentin , proliferative vitreoretinopathy , bisulfite sequencing , chemistry , biology , gene expression , cell , retinal , biochemistry , dna , immunohistochemistry , gene , immunology , retinal detachment

The purpose of this study was to evaluate expression of methyl-CpG-binding protein 2 (MeCP2) in epiretinal membranes from patients with proliferative vitreoretinopathy (PVR) and to investigate effects of inhibition of MeCP2 and DNA methylation on transforming growth factor (TGF)-β-induced retinal pigment epithelial (RPE) cell transdifferentiation.

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