Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina | Zendy

Siva P. Kambhampati | Zendy; Alexander J Clunies-Ross | Zendy; Imran Ahmed Bhutto | Zendy; Manoj K. Mishra | Zendy; Malia M. Edwards | Zendy; D. Scott McLeod | Zendy; Rangaramanujam M. Kannan | Zendy; Gerard A. Lutty | Zendy

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Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina

Author(s) -

Siva P. Kambhampati,

Alexander J Clunies-Ross,

Imran Ahmed Bhutto,

Manoj K. Mishra,

Malia M. Edwards,

D. Scott McLeod,

Rangaramanujam M. Kannan,

Gerard A. Lutty

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-16250

Subject(s) - microglia , retina , macrophage , ischemia , dendrimer , medicine , chemistry , inflammation , immunology , neuroscience , biology , in vitro , biochemistry

Microglial activation and associated neuroinflammation play a key role in the pathogenesis of many diseases of the retina, including viral infection, diabetes, and retinal degeneration. Strategies to target activated microglia and macrophages and attenuate inflammation may be valuable in treating these diseases. We seek to develop dendrimer-based formulations that target retinal microglia and macrophages in a pathology-dependent manner, and deliver drugs, either intravenously or intravitreally.

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