Cosmetic Preservatives as Therapeutic Corneal and Scleral Tissue Cross-Linking Agents | Zendy

Natasha Babar | Zendy; MyungHee Kim | Zendy; Kai Cao | Zendy; Y. Shimizu | Zendy; S.-Y. Kim | Zendy; Akira Takaoka | Zendy; Stephen L. Trokel | Zendy; David C. Paik | Zendy

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Cosmetic Preservatives as Therapeutic Corneal and Scleral Tissue Cross-Linking Agents

Author(s) -

Natasha Babar,

MyungHee Kim,

Kai Cao,

Y. Shimizu,

S.-Y. Kim,

Akira Takaoka,

Stephen L. Trokel,

David C. Paik

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-16035

Subject(s) - cornea , trypan blue , chemistry , sclera , toxicity , preservative , urea , cytotoxicity , pharmacology , ophthalmology , food science , medicine , organic chemistry , biochemistry , cell , in vitro

Previously, aliphatic β-nitroalcohols (BNAs) have been studied as a means to chemically induce tissue cross-linking (TXL) of cornea and sclera. There are a number of related and possibly more potent agents, known as formaldehyde releasers (FARs), that are in commercial use as preservatives in cosmetics and other personal care products. The present study was undertaken in order to screen such compounds for potential clinical utility as therapeutic TXL agents.

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