Open AccessCosmetic Preservatives as Therapeutic Corneal and Scleral Tissue Cross-Linking Agents
Author(s) -
Natasha Babar,
MiJung Kim,
Kerry Cao,
Yukari Shimizu,
SuYoung Kim,
Anna Takaoka,
Stephen L. Trokel,
David C. Paik
Publication year - 2015
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-16035
Subject(s) - cornea , trypan blue , chemistry , sclera , toxicity , preservative , urea , cytotoxicity , pharmacology , ophthalmology , food science , medicine , organic chemistry , biochemistry , cell , in vitro
Previously, aliphatic β-nitroalcohols (BNAs) have been studied as a means to chemically induce tissue cross-linking (TXL) of cornea and sclera. There are a number of related and possibly more potent agents, known as formaldehyde releasers (FARs), that are in commercial use as preservatives in cosmetics and other personal care products. The present study was undertaken in order to screen such compounds for potential clinical utility as therapeutic TXL agents.