TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium | Zendy

Peter Y. Zhao | Zendy; Geliang Gan | Zendy; Shaomin Peng | Zendy; Shao-Bin Wang | Zendy; Bo Chen | Zendy; Ron A. Adelman | Zendy; Lawrence J. Rizzolo | Zendy

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TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium

Author(s) -

Peter Y. Zhao,

Geliang Gan,

Shaomin Peng,

Shao-Bin Wang,

Bo Chen,

Ron A. Adelman,

Lawrence J. Rizzolo

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-15738

Subject(s) - transient receptor potential channel , microbiology and biotechnology , apical membrane , trpv4 , chloride channel , apical cell , chemistry , voltage dependent calcium channel , extracellular , calcium , retinal pigment epithelium , biophysics , biology , biochemistry , cell , receptor , retinal , membrane , organic chemistry

Calcium regulates many functions of the RPE. Its concentration in the subretinal space and RPE cytoplasm is closely regulated. Transient receptor potential (TRP) channels are a superfamily of ion channels that are moderately calcium-selective. This study investigates the subcellular localization and potential functions of TRP channels in a first-passage culture model of human fetal RPE (hfRPE).

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