Open AccessCannabinoid-Induced Chemotaxis in Bovine Corneal Epithelial Cells
Author(s) -
Natalia Murataeva,
Shimin Li,
Olivia Oehler,
Sally Miller,
Amey Dhopeshwarkar,
Sherry Shu Jung Hu,
Joseph A. Bonanno,
Heather Bradshaw,
Ken Mackie,
Douglas McHugh,
Alex Straiker
Publication year - 2015
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-15675
Subject(s) - cannabinoid receptor , microbiology and biotechnology , endocannabinoid system , cannabinoid , chemotaxis , receptor , biology , signal transduction , protein kinase a , gpr18 , cannabinoid receptor type 2 , mapk/erk pathway , agonist , chemistry , kinase , biochemistry
Cannabinoid CB1 receptors are found in abundance in the vertebrate eye, with most tissue types expressing this receptor. However, the function of CB1 receptors in corneal epithelial cells (CECs) is poorly understood. Interestingly, the corneas of CB1 knockout mice heal more slowly after injury via a mechanism proposed to involve protein kinase B (Akt) activation, chemokinesis, and cell proliferation. The current study examined the role of cannabinoids in CEC migration in greater detail.