Open AccessEndothelial TWIST1 Promotes Pathological Ocular Angiogenesis
Author(s) -
Jie Li,
Chi-Hsiu Liu,
Ye Sun,
Yan Gong,
Zhongjie Fu,
Lucy Evans,
Ke Tian,
Aimee M. Juan,
Christian G. Hurst,
Akiko Mammoto,
Jing Chen
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-15623
Subject(s) - angiogenesis , sprouting angiogenesis , neovascularization , vascular endothelial growth factor , conditional gene knockout , pathology , endothelial stem cell , pathological , vascular endothelial growth factor a , medicine , choroidal neovascularization , cancer research , biology , retinal , ophthalmology , phenotype , in vitro , biochemistry , vegf receptors , gene
Pathological neovessel formation impacts many blinding vascular eye diseases. Identification of molecular signatures distinguishing pathological neovascularization from normal quiescent vessels is critical for developing new interventions. Twist-related protein 1 (TWIST1) is a transcription factor important in tumor and pulmonary angiogenesis. This study investigated the potential role of TWIST1 in modulating pathological ocular angiogenesis in mice.