In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT | Zendy

Leon C. Ho | Zendy; Bo Wang | Zendy; Ian P. Conner | Zendy; Yolandi van der Merwe | Zendy; Richard A. Bilonick | Zendy; SeongGi Kim | Zendy; EX Wu | Zendy; Ian A. Sigal | Zendy; Gadi Wollstein | Zendy; Joel S. Schuman | Zendy; Kevin C. Chan | Zendy

Open Access

In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT

Author(s) -

Leon C. Ho,

Bo Wang,

Ian P. Conner,

Yolandi van der Merwe,

Richard A. Bilonick,

SeongGi Kim,

EX Wu,

Ian A. Sigal,

Gadi Wollstein,

Joel S. Schuman,

Kevin C. Chan

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-15552

Subject(s) - diffusion mri , white matter , fractional anisotropy , corpus callosum , retinal , optic nerve , magnetic resonance imaging , diffuse axonal injury , splenium , optic tract , neuroscience , anatomy , ophthalmology , pathology , chemistry , medicine , biology , traumatic brain injury , radiology , psychiatry

Excitotoxicity has been linked to the pathogenesis of ocular diseases and injuries and may involve early degeneration of both anterior and posterior visual pathways. However, their spatiotemporal relationships remain unclear. We hypothesized that the effects of excitotoxic retinal injury (ERI) on the visual system can be revealed in vivo by diffusion tensor magnetic resonance imagining (DTI), manganese-enhanced magnetic resonance imagining (MRI), and optical coherence tomography (OCT).

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