Exogenous Superoxide Dismutase Mimetic Without Scavenging H2O2 Causes Photoreceptor Damage in a Rat Model for Oxygen-Induced Retinopathy | Zendy

S. Jivabhai Patel | Zendy; Fayez Bany-Mohammed | Zendy; Leah McNally | Zendy; Gloria B. Valencia | Zendy; Douglas R. Lazzaro | Zendy; Jacob V. Aranda | Zendy; Kay D. Beharry | Zendy

Open Access

Exogenous Superoxide Dismutase Mimetic Without Scavenging H2O2 Causes Photoreceptor Damage in a Rat Model for Oxygen-Induced Retinopathy

Author(s) -

S. Jivabhai Patel,

Fayez Bany-Mohammed,

Leah McNally,

Gloria B. Valencia,

Douglas R. Lazzaro,

Jacob V. Aranda,

Kay D. Beharry

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-15321

Subject(s) - oxidative stress , superoxide dismutase , reactive oxygen species , antioxidant , hypoxia (environmental) , hyperoxia , oxidative phosphorylation , andrology , superoxide , chemistry , retinal , oxygen , medicine , endocrinology , biochemistry , enzyme , organic chemistry

Frequent, brief intermittent episodes of hypoxia (IH) during hyperoxia increase reactive oxygen species in the immature retina with compromised antioxidant systems, thus leading to oxygen-induced retinopathy (OIR). We examined the hypothesis that early exposure to a mimetic of superoxide dismutase (SOD), the first line of defense against oxidative stress, will decrease IH-induced reactive oxygen species (ROS) and prevent severe OIR in our rat model.

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