Skewed Expression of the Genes Encoding Epigenetic Modifiers in High-Risk Uveal Melanoma | Zendy

Nola S. Herlihy | Zendy; Mehmet Doğrusöz | Zendy; T. Huibertus van Essen | Zendy; J. William Harbour | Zendy; Pieter A. van der Velden | Zendy; Marja C.J.A. van Eggermond | Zendy; Geert W. Haasnoot | Zendy; Peter J. van den Elsen | Zendy; Martine J. Jager | Zendy

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Skewed Expression of the Genes Encoding Epigenetic Modifiers in High-Risk Uveal Melanoma

Author(s) -

Nola S. Herlihy,

Mehmet Doğrusöz,

T. Huibertus van Essen,

J. William Harbour,

Pieter A. van der Velden,

Marja C.J.A. van Eggermond,

Geert W. Haasnoot,

Peter J. van den Elsen,

Martine J. Jager

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-15250

Subject(s) - epigenetics , monosomy , biology , dna methylation , genetics , cancer research , ezh2 , gene , cpg site , microbiology and biotechnology , gene expression , chromosome , karyotype

Monosomy 3 (M3) or the presence of a specific RNA expression profile, known as class 2, is strongly associated with death from uveal melanoma (UM). Given the important role of epigenetic processes in cancer development and progression, we compared the transcriptional profiles of a selection of epigenetic regulators between primary UM with a good and a bad prognosis.

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