Modeling of Human Uveal Melanoma in Zebrafish Xenograft Embryos | Zendy

Wietske van der Ent | Zendy; Claudia Burrello | Zendy; Amina F.A.S. Teunisse | Zendy; Bruce R. Ksander | Zendy; Pieter A. van der Velden | Zendy; Martine J. Jager | Zendy; Aart G. Jochemsen | Zendy; B. Ewa SnaarJagalska | Zendy

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Modeling of Human Uveal Melanoma in Zebrafish Xenograft Embryos

Author(s) -

Wietske van der Ent,

Claudia Burrello,

Amina F.A.S. Teunisse,

Bruce R. Ksander,

Pieter A. van der Velden,

Martine J. Jager,

Aart G. Jochemsen,

B. Ewa SnaarJagalska

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-15202

Subject(s) - melanoma , dasatinib , zebrafish , cancer research , xenotransplantation , ocular melanoma , malignancy , medicine , biology , transplantation , pathology , imatinib , biochemistry , myeloid leukemia , gene

Uveal melanoma (UM) is fatal in up to 50% of patients because of liver metastases that are refractory to therapies currently available. While murine xenograft models for human uveal melanoma are available, they have limited utility for screening large compound libraries in drug discovery studies. Therefore, new robust preclinical models are needed that can efficiently evaluate drug efficacy for treatment of this malignancy.

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