Open Accessγδ T Cells as a Major Source of IL-17 Production During Age-Dependent RPE Degeneration
Author(s) -
Zhen-Yang Zhao,
Pei Xu,
Zuliang Jie,
Yiqin Zuo,
Bo Yu,
Lynn Soong,
Jiaren Sun,
Yan Chen,
Jiyang Cai
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-15166
Subject(s) - retina , biology , flow cytometry , macular degeneration , retinal , inflammation , foxp3 , cd3 , retinal degeneration , pathology , retinal pigment epithelium , cd8 , microglia , immune system , immunology , medicine , ophthalmology , biochemistry , neuroscience
Chronic inflammation is a key factor contributing to the progression of age-related macular degeneration (AMD). The goals of the current study were to develop an improved mouse model with retinal pathologic features similar to those of AMD and to characterize the immunoreactive cells in the outer retina and choroid during degeneration of the retinal pigment epithelium (RPE).