Open AccessEyelid Closure in Embryogenesis Is Required for Ocular Adnexa Development
Author(s) -
Qingxi Meng,
Maureen Mongan,
Vinicius Carreira,
Hisaka Kurita,
Chia-Yang Liu,
Winston W.Y. Kao,
Ying Xia
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-15155
Subject(s) - eyelid , closure (psychology) , medicine , ophthalmology , optometry , political science , law
Mammalian eye development requires temporary fusion of the upper and lower eyelids in embryogenesis. Failure of lid closure in mice leads to an eye open at birth (EOB) phenotype. Many genetic mutant strains develop this phenotype and studies of the mutants lead to a better understanding of the signaling mechanisms of morphogenesis. The present study investigates the roles of lid closure in eye development.