Eyelid Closure in Embryogenesis Is Required for Ocular Adnexa Development | Zendy

Qinghang Meng | Zendy; Maureen Mongan | Zendy; Vinicius Carreira | Zendy; Hisaka Kurita | Zendy; ChiaYang Liu | Zendy; Winston W.Y. Kao | Zendy; Ying Xia | Zendy

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Eyelid Closure in Embryogenesis Is Required for Ocular Adnexa Development

Author(s) -

Qinghang Meng,

Maureen Mongan,

Vinicius Carreira,

Hisaka Kurita,

ChiaYang Liu,

Winston W.Y. Kao,

Ying Xia

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-15155

Subject(s) - eyelid , closure (psychology) , medicine , ophthalmology , optometry , political science , law

Mammalian eye development requires temporary fusion of the upper and lower eyelids in embryogenesis. Failure of lid closure in mice leads to an eye open at birth (EOB) phenotype. Many genetic mutant strains develop this phenotype and studies of the mutants lead to a better understanding of the signaling mechanisms of morphogenesis. The present study investigates the roles of lid closure in eye development.

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