Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma | Zendy

Dorota L. Stankowska | Zendy; Alena Z. Minton | Zendy; Margaret Rutledge | Zendy; Brett Mueller | Zendy; Nitasha Phatak | Zendy; Shaoqing He | Zendy; Haiying Ma | Zendy; Michael J. Forster | Zendy; Thomas Yorio | Zendy; Raghu R. Krishnamoorthy | Zendy

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Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma

Author(s) -

Dorota L. Stankowska,

Alena Z. Minton,

Margaret Rutledge,

Brett Mueller,

Nitasha Phatak,

Shaoqing He,

Haiying Ma,

Michael J. Forster,

Thomas Yorio,

Raghu R. Krishnamoorthy

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-15008

Subject(s) - neuroprotection , optic nerve , glaucoma , ophthalmology , axon , retinal ganglion cell , retina , biology , medicine , neuroscience

Glaucoma is an optic neuropathy commonly associated with elevated intraocular pressure (IOP), leading to optic nerve head (ONH) cupping, axon loss, and apoptosis of retinal ganglion cells (RGCs), which could ultimately result in blindness. Brn3b is a class-4 POU domain transcription factor that plays a key role in RGC development, axon outgrowth, and pathfinding. Previous studies suggest that a decrease in Brn3b levels occurs in animal models of glaucoma. The goal of this study was to determine if adeno-associated virus (AAV)-directed overexpression of the Brn3b protein could have neuroprotective effects following elevated IOP-mediated neurodegeneration.

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