Constitutive and LPS-Induced Expression of MCP-1 and IL-8 by Human Uveal Melanocytes In Vitro and Relevant Signal Pathways | Zendy

DanNing Hu | Zendy; Mingchao Bi | Zendy; David Y. Zhang | Zendy; Fei Ye | Zendy; Steven A. McCormick | Zendy; ChiChao Chan | Zendy

Open Access

Constitutive and LPS-Induced Expression of MCP-1 and IL-8 by Human Uveal Melanocytes In Vitro and Relevant Signal Pathways

Author(s) -

DanNing Hu,

Mingchao Bi,

David Y. Zhang,

Fei Ye,

Steven A. McCormick,

ChiChao Chan

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-14685

Subject(s) - chemokine , p38 mitogen activated protein kinases , interleukin 8 , monocyte , mapk/erk pathway , ccl2 , lipopolysaccharide , microbiology and biotechnology , proinflammatory cytokine , signal transduction , kinase , biology , protein kinase a , secretion , chemistry , cytokine , immunology , endocrinology , inflammation

Melanocytes are one of the major cellular components in the uvea. Interleukin-8/CXCL8 and monocyte chemoattractant protein-1 (MCP-1/CCL2) are the two most important proinflammatory chemokines. We studied the constitutive and lipopolysaccharide (LPS)-induced expression of IL-8 and MCP-1 in cultured human uveal melanocytes (UM) and explored the relevant signal pathways.

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