Targeted Delivery of Antiglaucoma Drugs to the Supraciliary Space Using Microneedles | Zendy

Yoo C. Kim | Zendy; Henry F. Edelhauser | Zendy; Mark R. Prausnitz | Zendy

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Targeted Delivery of Antiglaucoma Drugs to the Supraciliary Space Using Microneedles

Author(s) -

Yoo C. Kim,

Henry F. Edelhauser,

Mark R. Prausnitz

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-14651

Subject(s) - medicine , brimonidine , intraocular pressure , sclera , ciliary body , ophthalmology , glaucoma , choroid , pharmacology , anesthesia , retina , physics , optics

In this work, we tested the hypothesis that highly targeted delivery of antiglaucoma drugs to the supraciliary space by using a hollow microneedle allows dramatic dose sparing of the drug compared to topical eye drops. The supraciliary space is the most anterior portion of the suprachoroidal space, located below the sclera and above the choroid and ciliary body.

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