Open AccessProtease-Activated Receptor 2 (PAR2) Is Upregulated byAcanthamoebaPlasminogen Activator (aPA) and Induces Proinflammatory Cytokine in Human Corneal Epithelial Cells
Author(s) -
Trivendra Tripathi,
Mahshid Abdi,
Hassan Alizadeh
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-14486
Subject(s) - proinflammatory cytokine , acanthamoeba , receptor , chemokine , plasminogen activator , biology , microbiology and biotechnology , cytokine , downregulation and upregulation , thrombomodulin , urokinase receptor , thrombin , immunology , endocrinology , biochemistry , inflammation , platelet , gene
Acanthamoeba plasminogen activator (aPA) is a serine protease elaborated by Acanthamoeba trophozoites that facilitates the invasion of trophozoites to the host and contributes to the pathogenesis of Acanthamoeba keratitis (AK). The aim of this study was to explore if aPA stimulates proinflammatory cytokine in human corneal epithelial (HCE) cells via the protease-activated receptors (PARs) pathway.