Open AccessCCR7 Is Critical for the Induction and Maintenance of Th17 Immunity in Dry Eye Disease
Author(s) -
Shilpa Kodati,
Sunil K. Chauhan,
Yihe Chen,
Thomas H. Dohlman,
Parisa Karimian,
Daniel R. Saban,
Reza Dana
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-14481
Subject(s) - c c chemokine receptor type 7 , immunology , medicine , chemokine , blockade , chemokine receptor , isotype , immunity , t cell , immune system , antibody , receptor , monoclonal antibody
We characterized antigen-presenting cell (APC)-relevant chemokine receptor expression in dry eye disease (DED), and investigated the effect of topical CC chemokine receptor (CCR)-7 blockade specifically on Th17 cell immunity and dry eye disease severity.
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