Endogenous Fluorophores Enable Two-Photon Imaging of the Primate Eye | Zendy

Grażyna Palczewska | Zendy; Marcin Golczak | Zendy; David R. Williams | Zendy; Jennifer J. Hunter | Zendy; Krzysztof Palczewski | Zendy

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Endogenous Fluorophores Enable Two-Photon Imaging of the Primate Eye

Author(s) -

Grażyna Palczewska,

Marcin Golczak,

David R. Williams,

Jennifer J. Hunter,

Krzysztof Palczewski

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-14395

Subject(s) - retinoid , retina , retinal , primate , fluorescence , fluorescence lifetime imaging microscopy , retinol , chemistry , biology , human eye , biophysics , biochemistry , neuroscience , optics , retinoic acid , vitamin , physics , gene

Noninvasive two-photon imaging of a living mammalian eye can reveal details of molecular processes in the retina and RPE. Retinyl esters and all-trans-retinal condensation products are two types of retinoid fluorophores present in these tissues. We measured the content of these two types of retinoids in monkey and human eyes to validate the potential of two-photon imaging for monitoring retinoid changes in human eyes.

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