Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy | Zendy

Renu A. Kowluru | Zendy; Júlia M. Santos | Zendy; Qing Peter Wild Zhong | Zendy

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Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy

Author(s) -

Renu A. Kowluru,

Júlia M. Santos,

Qing Peter Wild Zhong

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-14383

Subject(s) - sod2 , sirtuin 1 , oxidative stress , acetylation , diabetic retinopathy , resveratrol , apoptosis , matrix metalloproteinase , endocrinology , retinal , chemistry , medicine , biology , diabetes mellitus , downregulation and upregulation , superoxide dismutase , biochemistry , gene

In the pathogenesis of diabetic retinopathy, matrix metalloproteinase (MMP)-9 damages retinal mitochondria, activating the apoptotic machinery. Transcription of MMP-9 is regulated by nuclear factor kappa B (NF-κB), and the activation of NF-κB is modulated by the acetylation of its p65 subunit. Sirtuin 1 (Sirt1), a deacetylase, plays an important role in the acetylation-deacetylation of p65. The goal of this study is to investigate the role of Sirt1 in the activation of MMP-9 in diabetic retinopathy.

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