Open AccessSirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
Author(s) -
Renu A. Kowluru,
Júlia Matzenbacher dos Santos,
Qing Zhong
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-14383
Subject(s) - sod2 , sirtuin 1 , oxidative stress , acetylation , diabetic retinopathy , resveratrol , apoptosis , matrix metalloproteinase , endocrinology , retinal , chemistry , medicine , biology , diabetes mellitus , downregulation and upregulation , superoxide dismutase , biochemistry , gene
In the pathogenesis of diabetic retinopathy, matrix metalloproteinase (MMP)-9 damages retinal mitochondria, activating the apoptotic machinery. Transcription of MMP-9 is regulated by nuclear factor kappa B (NF-κB), and the activation of NF-κB is modulated by the acetylation of its p65 subunit. Sirtuin 1 (Sirt1), a deacetylase, plays an important role in the acetylation-deacetylation of p65. The goal of this study is to investigate the role of Sirt1 in the activation of MMP-9 in diabetic retinopathy.