Bioactive Lysophospholipids Generated by Hepatic Lipase Degradation of Lipoproteins Lead to Complement Activation via the Classical Pathway | Zendy

Wanchao Ma | Zendy; David C. Paik | Zendy; Gaetano R. Barile | Zendy

Open Access

Bioactive Lysophospholipids Generated by Hepatic Lipase Degradation of Lipoproteins Lead to Complement Activation via the Classical Pathway

Author(s) -

Wanchao Ma,

David C. Paik,

Gaetano R. Barile

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.14-14352

Subject(s) - complement system , chemistry , biochemistry , very low density lipoprotein , lipoprotein , hepatic lipase , phospholipase a , cholesterol , phospholipase a2 , enzyme , biology , immunology , antibody

We determined bioactivity of lysophospholipids generated by degradation of the low-density (LDL), very low-density (VLDL), and high-density (HDL) lipoproteins with hepatic lipase (HL), cholesterol esterase (CE), and lipoprotein-associated phospholipase A2 (Lp-PLA2).

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