Open AccessAntagonizing c-Cbl Enhances EGFR-Dependent Corneal Epithelial Homeostasis
Author(s) -
Jamie Rush,
Michael A. Boeving,
William L. Berry,
Brian P. Ceresa
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.14-14133
Subject(s) - corneal epithelium , microbiology and biotechnology , gene knockdown , epidermal growth factor receptor , ubiquitin ligase , receptor , wound healing , in vivo , cancer research , ubiquitin , chemistry , phosphorylation , in vitro , biology , cornea , biochemistry , immunology , apoptosis , neuroscience , gene
In many cell types, the E3 ubiquitin ligase, c-Cbl, induces ligand-dependent ubiquitylation of the epidermal growth factor receptor (EGFR) and targets the receptor for lysosomal degradation. The goal of this study was to determine whether c-Cbl is a negative regulator of EGFR in the corneal epithelium and if it can be inhibited to promote corneal epithelial homeostasis.