Role of Angiopoietin-2 in Corneal Lymphangiogenesis | Zendy

Don Yuen | Zendy; Sammy Grimaldo | Zendy; Roberto Sessa | Zendy; Tatiana Ecoiffier | Zendy; Tan Truong | Zendy; Eric C. Huang | Zendy; Michael Bernas | Zendy; Sarah Daley | Zendy; Marlys H. Witte | Zendy; Lu Chen | Zendy

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Role of Angiopoietin-2 in Corneal Lymphangiogenesis

Author(s) -

Don Yuen,

Sammy Grimaldo,

Roberto Sessa,

Tatiana Ecoiffier,

Tan Truong,

Eric C. Huang,

Michael Bernas,

Sarah Daley,

Marlys H. Witte,

Lu Chen

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-13779

Subject(s) - lymphangiogenesis , lymphatic system , cornea , in vivo , angiopoietin , angiopoietin receptor , gene knockdown , cancer research , in vitro , lymphatic endothelium , corneal neovascularization , small interfering rna , pathology , metastasis , immunology , medicine , microbiology and biotechnology , chemistry , biology , angiogenesis , cancer , neovascularization , ophthalmology , cell culture , vascular endothelial growth factor , transfection , vegf receptors , genetics , biochemistry

Lymphatic research has progressed rapidly in recent years. Lymphatic dysfunction has been found in myriad disorders from cancer metastasis to transplant rejection; however, effective treatment for lymphatic disorders is still limited. This study investigates the role of angiopoietin-2 (Ang-2) in corneal inflammatory lymphangiogenesis (LG) in vivo and in lymphatic endothelial cell (LEC) functions in vitro.

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