Cone Photoreceptors Develop Normally in the Absence of Functional Rod Photoreceptors in a Transgenic Swine Model of Retinitis Pigmentosa | Zendy

Juan P. Fernandez de Castro | Zendy; Patrick A. Scott | Zendy; James W. Fransen | Zendy; James Demas | Zendy; Paul J. DeMarco | Zendy; Henry J. Kaplan | Zendy; Maureen A. McCall | Zendy

Open Access

Cone Photoreceptors Develop Normally in the Absence of Functional Rod Photoreceptors in a Transgenic Swine Model of Retinitis Pigmentosa

Author(s) -

Juan P. Fernandez de Castro,

Patrick A. Scott,

James W. Fransen,

James Demas,

Paul J. DeMarco,

Henry J. Kaplan,

Maureen A. McCall

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-13724

Subject(s) - photopic vision , scotopic vision , retinitis pigmentosa , biology , retinal , rhodopsin , retina , electroretinography , retinal degeneration , anatomy , ophthalmology , neuroscience , medicine , biochemistry

Human and swine retinas have morphological and functional similarities. In the absence of primate models, the swine is an attractive model to study retinal function and disease, with its cone-rich visual streak, our ability to manipulate their genome, and the differences in susceptibility of rod and cone photoreceptors to disease. We characterized the normal development of cone function and its subsequent decline in a P23H rhodopsin transgenic (TgP23H) miniswine model of autosomal dominant RP.

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