Open AccessVimentin Knockdown Decreases Corneal Opacity
Author(s) -
Subrata K. Das,
Isha Gupta,
Yang Kyung Cho,
Xiaohui Zhang,
Hironori Uehara,
Santosh Kumar Muddana,
Ashlie Bernhisel,
Bonnie Archer,
Balamurali K. Ambati
Publication year - 2014
Publication title -
investigative ophthalmology and visual science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.13-13494
Subject(s) - gene knockdown , vimentin , stroma , fibrosis , myofibroblast , green fluorescent protein , wound healing , microbiology and biotechnology , biology , pathology , medicine , immunology , gene , immunohistochemistry , genetics
Wound induced corneal fibrosis can lead to permanent visual impairment. Keratocyte activation and differentiation play a key role in fibrosis, and vimentin, a major structural type III intermediate filament, is a required component of this process. The purpose of our study was to develop a nonviral therapeutic strategy for treating corneal fibrosis in which we targeted the knockdown of vimentin.