Enhanced Wound Healing, Kinase and Stem Cell Marker Expression in Diabetic Organ-Cultured Human Corneas Upon MMP-10 and Cathepsin F Gene Silencing | Zendy

Mehrnoosh Saghizadeh | Zendy; Irina Epifantseva | Zendy; David M. Hemmati | Zendy; Chantelle A. Ghiam | Zendy; William J. Brunken | Zendy; Alexander V. Ljubimov | Zendy

Open Access

Enhanced Wound Healing, Kinase and Stem Cell Marker Expression in Diabetic Organ-Cultured Human Corneas Upon MMP-10 and Cathepsin F Gene Silencing

Author(s) -

Mehrnoosh Saghizadeh,

Irina Epifantseva,

David M. Hemmati,

Chantelle A. Ghiam,

William J. Brunken,

Alexander V. Ljubimov

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-13233

Subject(s) - wound healing , gene silencing , small hairpin rna , stem cell , biology , microbiology and biotechnology , corneal epithelium , gene knockdown , cornea , cell culture , immunology , gene , biochemistry , genetics , neuroscience

Diabetic corneas overexpress proteinases including matrix metalloproteinase-10 (M10) and cathepsin F (CF). Our purpose was to assess if silencing M10 and CF in organ-cultured diabetic corneas using recombinant adenovirus (rAV)-driven small hairpin RNA (rAV-sh) would normalize slow wound healing, and diabetic and stem cell marker expression.

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