AMA0076, a Novel, Locally Acting Rho Kinase Inhibitor, Potently Lowers Intraocular Pressure in New Zealand White Rabbits with Minimal Hyperemia | Zendy

Sarah Van de Velde | Zendy; Tine Van Bergen | Zendy; Davine Sijnave | Zendy; Karolien Hollanders | Zendy; Karolien Castermans | Zendy; Olivier Defert | Zendy; Dirk Leysen | Zendy; Evelien Vandewalle | Zendy; Lieve Moons | Zendy; Ingeborg Stalmans | Zendy

Open Access

AMA0076, a Novel, Locally Acting Rho Kinase Inhibitor, Potently Lowers Intraocular Pressure in New Zealand White Rabbits with Minimal Hyperemia

Author(s) -

Sarah Van de Velde,

Tine Van Bergen,

Davine Sijnave,

Karolien Hollanders,

Karolien Castermans,

Olivier Defert,

Dirk Leysen,

Evelien Vandewalle,

Lieve Moons,

Ingeborg Stalmans

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-13157

Subject(s) - intraocular pressure , trabecular meshwork , rho associated protein kinase , rho kinase inhibitor , glaucoma , potency , latanoprost , medicine , metabolite , lagomorpha , ocular hypertension , pharmacology , ophthalmology , kinase , in vitro , chemistry , biochemistry

To determine whether ROCK inhibition for the treatment of glaucoma can be improved by using novel, locally acting Rho kinase (ROCK) inhibitors, such as AMA0076, that lower IOP without inducing hyperemia.

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