In Vivo Downregulation of Innate and Adaptive Immune Responses in Corneal Allograft Rejection by HC-HA/PTX3 Complex Purified From Amniotic Membrane | Zendy

Hua He | Zendy; Yaohong Tan | Zendy; Stéphanie Duffort | Zendy; Víctor Pérez | Zendy; Scheffer C.G. Tseng | Zendy

Open Access

In Vivo Downregulation of Innate and Adaptive Immune Responses in Corneal Allograft Rejection by HC-HA/PTX3 Complex Purified From Amniotic Membrane

Author(s) -

Hua He,

Yaohong Tan,

Stéphanie Duffort,

Víctor Pérez,

Scheffer C.G. Tseng

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-13094

Subject(s) - in vivo , flow cytometry , ptx3 , macrophage polarization , downregulation and upregulation , foxp3 , chemistry , microbiology and biotechnology , immunology , in vitro , immune system , biology , inflammation , macrophage , biochemistry , gene

Heavy chain-hyaluronic acid (HC-HA)/PTX3 purified from human amniotic membrane (AM) was previously observed to suppress inflammatory responses in vitro. We now examine whether HC-HA/PTX3 is able to exert a similar effect in vivo, using murine models for keratitis and corneal allograft rejection.

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