Clusterin and Complement Activation in Exfoliation Glaucoma | Zendy

Ivo Doudevski | Zendy; Agueda Rostagno | Zendy; Mary K. Cowman | Zendy; Jeffrey M. Liebmann | Zendy; Robert Ritch | Zendy; Jorge Ghiso | Zendy

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Clusterin and Complement Activation in Exfoliation Glaucoma

Author(s) -

Ivo Doudevski,

Agueda Rostagno,

Mary K. Cowman,

Jeffrey M. Liebmann,

Robert Ritch,

Jorge Ghiso

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-12941

Subject(s) - clusterin , complement system , vitronectin , inflammation , pseudoexfoliation syndrome , chemistry , colocalization , anaphylatoxin , microbiology and biotechnology , medicine , glaucoma , immunology , biophysics , pathology , ophthalmology , biology , biochemistry , apoptosis , immune system , fibronectin , extracellular matrix

The study was done to better understand the biological significance of clusterin co-localization with the exfoliation deposits (XF deposits), and provide insight into a pathogenic mechanism involving activation of the complement system and its pro-inflammatory consequences in patients with exfoliation glaucoma.

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