Porous Poly(ε-Caprolactone) Scaffolds for Retinal Pigment Epithelium Transplantation | Zendy

Kevin J. McHugh | Zendy; Sarah L. Tao | Zendy; Magali SaintGeniez | Zendy

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Porous Poly(ε-Caprolactone) Scaffolds for Retinal Pigment Epithelium Transplantation

Author(s) -

Kevin J. McHugh,

Sarah L. Tao,

Magali SaintGeniez

Publication year - 2014

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-12833

Subject(s) - retinal pigment epithelium , transplantation , polyester , microbiology and biotechnology , chemistry , retinal , biophysics , materials science , biology , medicine , surgery , biochemistry , organic chemistry

Retinal pigment epithelium (RPE) transplantation is a promising strategy for the treatment of dry age-related macular degeneration (AMD). However, previous attempts at subretinal RPE cell transplantation have experienced limited success due to poor adhesion, organization, and function on aged or diseased Bruch's membrane. Instead, cell-based strategies may benefit from a synthetic scaffold that mimics the functions of healthy Bruch's membrane to promote the formation of a functional RPE monolayer while maintaining metabolite exchange between the vasculature and outer retina.

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