Orbital Fibroblasts From Thyroid Eye Disease Patients Differ in Proliferative and Adipogenic Responses Depending on Disease Subtype | Zendy

Ajay E. Kuriyan | Zendy; Collynn F. Woeller | Zendy; Charles W. O’Loughlin | Zendy; Richard P. Phipps | Zendy; Steven E. Feldon | Zendy

Open Access

Orbital Fibroblasts From Thyroid Eye Disease Patients Differ in Proliferative and Adipogenic Responses Depending on Disease Subtype

Author(s) -

Ajay E. Kuriyan,

Collynn F. Woeller,

Charles W. O’Loughlin,

Richard P. Phipps,

Steven E. Feldon

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-12741

Subject(s) - adipogenesis , oil red o , endocrinology , medicine , flow cytometry , cell growth , chemistry , biology , adipose tissue , microbiology and biotechnology , biochemistry

Thyroid eye disease (TED) patients are classified as type I (predominantly fat compartment enlargement) or type II (predominantly extraocular muscle enlargement) based on orbital imaging. Orbital fibroblasts (OFs) can be driven to proliferate or differentiate into adipocytes in vitro. We tested the hypothesis that type I OFs undergo more adipogenesis than type II OFs, whereas type II OFs proliferate more than type I OFs. We also examined the effect of cyclooxygenase (COX) inhibitors on OF adipogenesis and proliferation.

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