Endothelial Cell MicroRNA Expression in Human Late-Onset Fuchs' Dystrophy | Zendy

Mario Matthaei | Zendy; Jianfei Hu | Zendy; Laura Kallay | Zendy; Charles G. Eberhart | Zendy; Claus Cursiefen | Zendy; Jiang Qian | Zendy; EvaMaria Lackner | Zendy; Albert S. Jun | Zendy

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Endothelial Cell MicroRNA Expression in Human Late-Onset Fuchs' Dystrophy

Author(s) -

Mario Matthaei,

Jianfei Hu,

Laura Kallay,

Charles G. Eberhart,

Claus Cursiefen,

Jiang Qian,

EvaMaria Lackner,

Albert S. Jun

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-12689

Subject(s) - biology , downregulation and upregulation , microrna , extracellular matrix , microbiology and biotechnology , microarray analysis techniques , endothelium , gene expression , genetics , gene

MicroRNAs (miRNAs) are a class of endogenous noncoding RNA and post transcriptionally modulate gene expression during development and disease. Our study investigated the differential miRNA expression in human Fuchs' endothelial corneal dystrophy (FECD) compared with normal endothelium to identify miRNA sequences that are involved in the pathogenesis of FECD.

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