Computational Model for Oxygen Transport and Consumption in Human Vitreous | Zendy

Benjamen A. Filas | Zendy; YingBo Shui | Zendy; David C. Beebe | Zendy

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Computational Model for Oxygen Transport and Consumption in Human Vitreous

Author(s) -

Benjamen A. Filas,

YingBo Shui,

David C. Beebe

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-12609

Subject(s) - posterior vitreous detachment , vitrectomy , vitreous chamber , oxygen , chemistry , lens (geology) , oxygen transport , ophthalmology , biophysics , retinal detachment , retinal , biochemistry , optics , biology , eye disease , medicine , visual acuity , organic chemistry , physics , refractive error

Previous studies that measured liquefaction and oxygen content in human vitreous suggested that exposure of the lens to excess oxygen causes nuclear cataracts. Here, we developed a computational model that reproduced available experimental oxygen distributions for intact and degraded human vitreous in physiologic and environmentally perturbed conditions. After validation, the model was used to estimate how age-related changes in vitreous physiology and structure alter oxygen levels at the lens.

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