Bone Marrow Transplantation Transfers Age-Related Susceptibility to Neovascular Remodeling in Murine Laser-Induced Choroidal Neovascularization | Zendy

Diego G. EspinosaHeidmann | Zendy; Goldis Malek | Zendy; Priyatham S. Mettu | Zendy; Alejandro Caicedo | Zendy; Peter Saloupis | Zendy; Sarah Gach | Zendy; Askia K. Dun | Zendy; Peng Hu | Zendy; Maria-Grazia Spiga | Zendy; Scott W. Cousins | Zendy

Open Access

Bone Marrow Transplantation Transfers Age-Related Susceptibility to Neovascular Remodeling in Murine Laser-Induced Choroidal Neovascularization

Author(s) -

Diego G. EspinosaHeidmann,

Goldis Malek,

Priyatham S. Mettu,

Alejandro Caicedo,

Peter Saloupis,

Sarah Gach,

Askia K. Dun,

Peng Hu,

Maria-Grazia Spiga,

Scott W. Cousins

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-12546

Subject(s) - bone marrow , pathology , choroidal neovascularization , neovascularization , mesenchymal stem cell , medicine , transplantation , fibrosis , cd31 , macular degeneration , immunohistochemistry , biology , angiogenesis , cancer research , ophthalmology

Neovascular remodeling (NVR), the progression of small capillaries into large-caliber arterioles with perivascular fibrosis, represents a major therapeutic challenge in neovascular age-related macular degeneration (AMD). Neovascular remodeling occurs after laser-induced choroidal neovascularization (CNV) in aged but not young mice. Additionally, bone marrow-derived cells, including macrophages, endothelial precursor cells, and mesenchymal precursor cells, contribute to CNV severity. In this study, we investigated the impact of aged bone marrow transplantation (BMT) on the degree of fibrosis, size, and vascular morphology of CNV lesions in a mouse model of laser-induced CNV.

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