SIRT1 Promotes RGC Survival and Delays Loss of Function Following Optic Nerve Crush | Zendy

Ling Zuo | Zendy; Reas S. Khan | Zendy; Vivian Lee | Zendy; Kimberly Dine | Zendy; Wen Wu | Zendy; Kenneth S. Shindler | Zendy

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SIRT1 Promotes RGC Survival and Delays Loss of Function Following Optic Nerve Crush

Author(s) -

Ling Zuo,

Reas S. Khan,

Vivian Lee,

Kimberly Dine,

Wen Wu,

Kenneth S. Shindler

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-12157

Subject(s) - optic nerve , oxidative stress , retinal ganglion cell , crush injury , optic neuropathy , retina , resveratrol , endocrinology , medicine , biology , pharmacology , neuroscience , ophthalmology , surgery

Activation of SIRT1 deacetylase prevents retinal ganglion cell (RGC) loss in experimental optic neuritis, an inflammatory optic neuropathy. While mechanisms of this effect are not known, evidence suggests it involves reduction of oxidative stress. We hypothesized that SIRT1 reduces RGC loss due to oxidative stress in noninflammatory optic neuropathies, and examined effects following traumatic injury.

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