Regulation of Cdc42 Expression and Signaling Is Critical for Promoting Corneal Epithelial Wound Healing | Zendy

Swetha Pothula | Zendy; Haydee E. P. Bazán | Zendy; Gudiseva Chandrasekher | Zendy

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Regulation of Cdc42 Expression and Signaling Is Critical for Promoting Corneal Epithelial Wound Healing

Author(s) -

Swetha Pothula,

Haydee E. P. Bazán,

Gudiseva Chandrasekher

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-11955

Subject(s) - cdc42 , microbiology and biotechnology , wound healing , keratinocyte growth factor , epidermal growth factor , biology , hepatocyte growth factor , signal transduction , chemistry , cancer research , growth factor , immunology , receptor , biochemistry

Cdc42, a member of Rho GTPases (guanosine triphosphatases), participates in cytokine- and growth factor-controlled biological functions in mammalian tissues. Here, we examined Cdc42 role in corneal epithelial wound healing and the influence of hepatocyte, keratinocyte, and epidermal growth factor (HGF, KGF, and EGF)-mediated signaling on Cdc42.

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