Ion Transport Function of SLC4A11 in Corneal Endothelium | Zendy

Supriya S. Jalimarada | Zendy; Diego G. Ogando | Zendy; Eranga N. Vithana | Zendy; Joseph A. Bonanno | Zendy

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Ion Transport Function of SLC4A11 in Corneal Endothelium

Author(s) -

Supriya S. Jalimarada,

Diego G. Ogando,

Eranga N. Vithana,

Joseph A. Bonanno

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-11929

Subject(s) - bicarbonate , chemistry , corneal endothelium , intracellular ph , biophysics , intracellular , biochemistry , microbiology and biotechnology , endothelium , biology , endocrinology , organic chemistry

Mutations in SLC4A11, a member of the SLC4 superfamily of bicarbonate transporters, give rise to corneal endothelial cell dystrophies. SLC4A11 is a putative Na⁺ borate and Na⁺:OH⁻ transporter. Therefore we ask whether SLC4A11 in corneal endothelium transports borate (B[OH]₄⁻), bicarbonate (HCO3⁻), or hydroxyl (OH⁻) anions coupled to Na⁺.

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