The Influence of 13-cisRetinoic Acid on Human Meibomian Gland Epithelial Cells | Zendy

Juan Ding | Zendy; Wendy R. Kam | Zendy; Julia Dieckow | Zendy; David A. Sullivan | Zendy

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The Influence of 13-cisRetinoic Acid on Human Meibomian Gland Epithelial Cells

Author(s) -

Juan Ding,

Wendy R. Kam,

Julia Dieckow,

David A. Sullivan

Publication year - 2013

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.13-11863

Subject(s) - cell growth , retinoic acid , biology , programmed cell death , microbiology and biotechnology , meibomian gland , cancer research , cell , inflammation , endocrinology , cell culture , medicine , immunology , apoptosis , biochemistry , genetics , surgery , eyelid

Meibomian gland dysfunction (MGD) is a primary cause of dry eye disease. One of the risk factors for MGD is exposure to 13-cis retinoic acid (13-cis RA), a metabolite of vitamin A. However, the mechanism is not well understood. We hypothesize that 13-cis RA inhibits cell proliferation, promotes cell death, alters gene and protein expressions, and attenuates cell survival pathways in human meibomian gland epithelial cells.

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